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▼ Prognosis In aldolase B-deficient tissues, cytoplasmic accumulation of fructose-one-phosphate leads to sequestration of inorganic phosphate with resulting activation of AMP deaminase that catalyzes the irreversible deamination of AMP to IMP (inosine monophosphate), a precursor of uric acid. From the cytoplasm, AMP, ADP, and ATP are managed in a… Read More

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